bal Levels of Specific Histone Modifications and an enetic Gene Signature Predict Prostate Cancer

نویسندگان

  • Karen Chiam
  • Grant Buchanan
  • Shalini Jindal
  • Tanya K. Day
  • Mervyn Thomas
  • A. Pickering
  • Melissa A. O'Loughlin
  • Natalie K. Ryan
  • Wendy A. Raymond
  • Lisa G. Horvath
  • Phillip D. Stricker
  • Villis R. Marshall
  • Robert L. Sutherland
  • Susan M. Henshall
  • L. Gerald
  • Howard I. Scher
  • Gail P. Risbridger
  • Judith A. Clements
  • Lisa M. Butler
  • D. Tilley
  • David J. Horsfall
چکیده

ianco-Miotto, Karen Chiam, Grant Buchanan, Shalini Jindal, Tanya K. Day, Mervyn Thomas, A. Pickering, Melissa A. O'Loughlin, Natalie K. Ryan, Wendy A. Raymond, Lisa G. Horvath, s G. Kench, Phillip D. Stricker, Villis R. Marshall, Robert L. Sutherland, Susan M. Henshall, L. Gerald, Howard I. Scher, Gail P. Risbridger, Judith A. Clements, Lisa M. Butler, e D. Tilley, David J. Horsfall, and Carmela Ricciardelli; for the Australian Prostate Cancer BioResource

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Investigation of Histone Lysine-Specific Demethylase 5D (KDM5D) Isoform Expression in Prostate Cancer Cell Lines: a System Approach

Background: It is now well-demonstrated that histone demethylases play an important role in developmental controls, cell-fate decisions, and a variety of diseases such as cancer. Lysine-specific demethylase 5D (KDM5D) is a male-specific histone demethylase that specifically demethylates di- and tri-methyl H3K4 at the start site of active genes. In this light, the aim of this study was to invest...

متن کامل

What is the most appropriate test in detecting prostate cancer in patients with intermediate prostate specific antigen levels?

  Abstract   Background: Regarding the variety of tests present for detecting and also screening   prostate cancer and also bearing in mind the advantages and disadvantages of   these tests we decided to re-evaluate these tests (total prostate specific antigen and all   of its modifications) in detecting prostate cancer in men with intermediate serum   PSAlevels.   Methods: Following a cross se...

متن کامل

Association between rs2735839 and Serum Prostate-specific Antigen Level Regarding Risk of Prostate Cancer in Iranian Population

Background and Objective: Prostate cancer is among the five common cancers in males. It is second cancer in terms of the age-standardized rate (ASR) (ASR=16.6) in Iran. The rs2735839 G/A, an intergenic polymorphism is located on chromosome 19q13.33 at 600 base pairs of the KLK3 gene untranslatable region. This gene which codes prostate-specific antigen (PSA) is used in the screening and diagnos...

متن کامل

اپی‌ژنتیک سرطان پستان: مقاله مروری

Stable molecular changes during cell division without any change in the sequence of DNA molecules is known as epigenetic. Molecular mechanisms involved in this process, including histone modifications, methylation of DNA, protein complex and RNA antisense. Cancer genome changes happen through a combination of DNA hypermethylation, long-term epigenetic silencing with heterozygosis loss and genom...

متن کامل

P-209: Decreased Expression of Histone Acetyltransferase CDY1 Gene in Testis Tissue May Lead to Decreased Expression of Transition Protein (TNP) and Protamine (PRM) Genes,Causing Male Infertility

Background: Infertility is a complex medical problem. About 15% of couples are infertile, and male infertility being involved in roughly 50% of the cases. Among these, many cases are associated with a severe impairment of spermatogenesis. During the last stage of spermatogenesis (spermiogenesis), sperm chromatin endures complex modifications in which histones are lost and depositioned with tran...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:

دوره   شماره 

صفحات  -

تاریخ انتشار 2010